Lower absolute numbers of CD4⁺ naive and CD8⁺ effector memory cells in peripheral blood are potential predictive indicators of renal endpoint events in patients with chronic kidney disease.

ABSTRACT: Background: There is no consensus on the distribution of T cell subsets during chronic kidney disease (CKD) progression. In this study, we aimed to investigate the levels of circulating T cell subsets in the peripheral blood of patients with CKD at various stages and the relationship between T cell parameters and renal endpoint events.Method: We selected 130 patients with non-dialysis stages I-V CKD and 75 healthy controls from Dongyang People's Hospital between February 2021 and March 2023. Multicolor flow cytometry was used to detect T cell subsets in patients at different stages of CKD.Result: The absolute CD4⁺ and CD8⁺ naïve T (TN)/central memory T (TCM), CD8⁺ effector memory T (TEM), and CD8⁺ terminally differentiated ef

SUBMITTER: Chen X 

PROVIDER: S-EPMC12404060 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature