From brain to behavior: Psychological resilience mediates associations between whole-brain resting-state connectivity and NSSI.

ABSTRACT:

Background

Non suicidal self injury (NSSI) is a public health concern, and its prevalence has increased significantly following the COVID-19 pandemic. Despite its rising incidence, the neurobiological mechanisms underlying NSSI behaviour in adolescents remain poorly understood.

Methods

A sample of 89 adolescents (46 NSSI positive, 43 NSSI negative) aged 15.39 ± 1.77 years was recruited from clinical settings. NSSI behaviour and psychological resilience were evaluated. Resting-state functional magnetic resonance imaging (Rs-fMRI) was conducted to examine brain connectivity patterns. Data analysis incorporated descriptive and inferential statistics, as well as support vector machine algorithms, to identify the neural correlates of NSSI and resilience.

Results

The NSSI p

SUBMITTER: Mehmood A 

PROVIDER: S-EPMC12404062 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature