Functional and taxonomic dysbiosis of the supragingival plaque metagenome in Behcet's disease.

ABSTRACT:

Background

Behçet's Disease (BD), a complex autoinflammatory disorder, is increasingly linked to microbial dysbiosis, yet the specific microbial signatures and their functional consequences remain incompletely characterized. Elucidating these alterations is crucial for understanding BD pathogenesis.

Objective

To identify distinct microbial community structures and functional potentials in supragingival plaque microbiomes of BD patients versus healthy controls (HC) using high-resolution shotgun metagenomic sequencing.

Methods

Supragingival plaque from 18 BD patients and 22 HCs was subjected to shotgun metagenomics. Analyses included alpha/beta diversity, taxonomic composition, and MetaCyc pathway abundance, with statistical comparisons.

Results

Despite similar a

SUBMITTER: Sapthanakorn T 

PROVIDER: S-EPMC12404063 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature