Low-density lipoprotein cholesterol and clinical outcomes in patients with liver cirrhosis: a nationwide cohort study.

ABSTRACT:

Background

The association between low-density lipoprotein cholesterol (LDL-C) levels and clinical outcomes in patients with liver cirrhosis (LC) remains unclear. In this study, we aimed to investigate the association between LDL-C levels and cardiovascular events, along with all-cause death in patients with LC, using a nationwide database.

Materials and methods

This retrospective cohort study included 303,988 patients with LC identified from the Korean National Health Insurance Service database who underwent health examinations between 2009 and 2017. Patients were categorised into six LDL-C groups (<70, 70-99, 100-129, 130-159, 160-189, and ≥190 mg/dL). The primary outcomes were (1) a composite of myocardial infarction and ischaemic stroke and (2) all-cause death.

Result

SUBMITTER: Kim BS 

PROVIDER: S-EPMC12404081 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature