Monodispersity Increases Adhesion Efficiency and Specificity for Ultrasound-Targeted Microbubbles.

ABSTRACT: Ultrasound molecular imaging with targeted microbubbles (MBs) can be used to noninvasively diagnose, monitor, and study the progression of different endothelial-associated diseases. Acoustic radiation force (F_rad) can initiate and enhance MB adhesion at the target site. The goal of this study was to elucidate the effects of various MB parameters on F_rad targeting. Monodisperse or polydisperse MBs with the immune-stealth cloaked (buried)-ligand architecture were conjugated with targeting RGD or nonspecific isotype control RAD peptides and then pumped through an α_vβ₃ integrin-coated microvessel phantom at a wall shear stress of 3.5 dyn/cm². Targeting was assessed by measuring MB attachment for varying F_rad

SUBMITTER: Navarro-Becerra JA 

PROVIDER: S-EPMC12404108 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature