A case of idiosyncratic drug-induced agranulocytosis because of sulbactam/ampicillin.

ABSTRACT: Idiosyncratic drug-induced agranulocytosis is a rare but life-threatening condition that requires immediate medical intervention. Although sulbactam/ampicillin (SBT/ABPC) is a widely used antibiotic, no prior case reports of its associated agranulocytosis were identified in our narrative literature review. We present a case of an 85-year-old man who developed agranulocytosis following SBT/ABPC treatment for pressure ulcer infection and aspiration pneumonia, accompanied by a narrative literature review. Awareness of this condition, prompt discontinuation of the suspected agent, and close monitoring of total white blood cell counts are essential for early detection and management of this life-threatening complication.

SUBMITTER: Toda K 

PROVIDER: S-EPMC12404175 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature