Sex-specific transcriptome dynamics of <i>Anopheles gambiae</i> during embryonic development.

ABSTRACT: Malaria-transmitting mosquitoes are extremely sexually dimorphic in their anatomy and behavior. Sex-specific gene expression in Anopheles gambiae is well studied in adult stages, but its onset during embryogenesis, apart from sex determination factors like Yob, remains largely unknown. Here, we report a comprehensive single-embryo transcriptome atlas of A. gambiae males and females to understand the earliest stages of establishing the sex-specific expression networks. Our data set reveals embryonic RNA isoform diversity, including a global shift toward distal alternative polyadenylation (APA) event sites during the maternal-to-zygotic genome transition. Sex-biased gene expression and alternative splicing are limited during embryogenesis, with most sex-specific patterns

SUBMITTER: Kalita AI 

PROVIDER: S-EPMC12404204 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature