Development of a bioactive, piezoelectric PVDF-TrFE scaffold with evaluation of tissue reaction for potential in nerve repair.

ABSTRACT: Current biomaterials for trauma-associated tissue repair often fail to recapitulate the complex signaling environment required for effective integration and regeneration, particularly in modulating immune responses post-implantation. To address these limitations, we developed a multi-cue electrospun scaffold incorporating physiologically relevant chemical, electrical, and physical signals. Using blend electrospinning, we functionalized poly(vinylidene fluoride-trifluoroethylene) (PVDF-TrFE) with cell-secreted, decellularized extracellular matrix (dECM) to enhance cellular responses and limit foreign body reactions. The resulting scaffolds were systematically characterized in vitro for their structural, biochemical, and piezoelectric properties, and evaluated for their ability to sup

SUBMITTER: Bryan AE 

PROVIDER: S-EPMC12404288 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature