Prediction of antipsychotic medication inception in antipsychotic-naive youth at clinical high risk for psychosis.

ABSTRACT:

Background

Antipsychotic (AP) medication in individuals at clinical high risk for psychosis (CHR-P) is not routinely recommended by clinical guidelines but is commonly prescribed. Since little is known about the predictors of AP inception in CHR-P, we analyzed data from two observational cohorts.

Methods

To avoid baseline predictors being confounded by previous treatment, participants were selected for analysis from the 764 participants at CHR-P enrolled in NAPLS-2 and the 710 enrolled in NAPLS-3 by excluding those with lifetime histories of AP use. Baseline clinical variables available in both studies were employed as predictors of subsequent AP inception over the next 6 months in univariable and multivariable analyses.

Results

Preliminary analyses indicated no impor

SUBMITTER: Mukhtar H 

PROVIDER: S-EPMC12404330 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature