Impact of schizophrenia-associated risk genes on brain functional networks and executive deficits: a study of individuals with schizophrenia and genetic high risk.

ABSTRACT:

Background

Schizophrenia (SCZ) and genetic high-risk (GHR) individuals exhibit deficits in brain functional networks and cognitive function, potentially impacted by SCZ risk genes. This study aims to delineate these impairments in SCZ and GHR individuals, and further explore how risk genes affect brain networks and executive function.

Methods

A total sample size of 292 participants (100 SCZ, 68 GHR, and 124 healthy controls [HCs]) in the study. The Wisconsin Card Sorting Test (WCST) and resting-state functional magnetic resonance imaging (rs-fMRI) are utilized to evaluate executive function and brain network topology. SCZ-related polygenic risk scores (SCZ-PRS) were used to evaluate genetic risk levels. WCST and PRS were not applied to all participants.

Results

Signif

SUBMITTER: Sun T 

PROVIDER: S-EPMC12404332 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature