PANoptosis-mediated mechanisms underlying AST elevation in Talaromyces marneffei infection.

ABSTRACT:

Background

Talaromyces marneffei (T. marneffei), a life-threatening opportunistic fungal pathogen, is endemic to Southeast Asia. Although elevated aspartate aminotransferase (AST) levels are commonly observed in infected individuals, the origin and mechanism of this phenomenon remain unclear. This study aimed to determine whether AST is a specific clinical indicator of T. marneffei infection and to investigate the underlying mechanisms associated with tissue damage and cell death.

Methods

We retrospectively analyzed clinical and laboratory data of HIV/AIDS patients with or without T. marneffei infection from the Fourth People's Hospital of Nanning, Guangxi. A murine model of T. marneffei infection was constructed to investigate AST distribution in tissues. Additionally, PANo

SUBMITTER: Wei W 

PROVIDER: S-EPMC12404362 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature