Antimalarial and neuroprotective effects of ethanolic extracts of the five-flower remedy in an experimental cerebral malaria model.

ABSTRACT: Cerebral malaria (CM), a life-threatening consequence of Plasmodium falciparum infection, is associated with a high fatality rate and long-term brain impairment in survivors. Despite advances in malaria treatment, effective therapies to mitigate the severe neurological consequences of CM remain limited. Consequently, novel antimalarial drugs with different mechanisms or neuroprotective advantages are urgently required. This study aimed to explore the potential antimalarial and neuroprotective properties of the five-flower remedy (FFR), a traditional herbal formulation, in experimental cerebral malaria (ECM). Male C57BL/6 mice were induced with Plasmodium berghei ANKA to establish the ECM model. The ethanolic extract of FFR (600 mg/kg) was assessed both as a monotherapy and in combination w

SUBMITTER: Plirat W 

PROVIDER: S-EPMC12404382 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature