Analysis of global, regional, and national burden and attributable risk factors of acute lymphoblastic leukemia and acute myeloid leukemia from 1990 to 2021.

ABSTRACT:

Background

Acute Leukemia (AL) is a prevalent subtype of leukemia, mainly including acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML). The disease burden of acute leukemia has significantly shifted in recent years. The aim of this study was to evaluate global trends in the burden of disease for ALL and AML from 1990 to 2021.

Methods

Data on ALL and AML, encompassing incidence, mortality, disability-adjusted life-years (DALYs), and associated risk factors from 1990 to 2021, were extracted from the Global Burden of Disease (GBD) 2021 database. Estimated annual percentage changes (EAPC) were calculated to assess the changes in age-standardized incidence rate (ASIR), age-standardized mortality rate (ASMR), and age-standardized DALYs rate (ASDR). The association

SUBMITTER: Ni H 

PROVIDER: S-EPMC12404455 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature