Transcriptional profiling identification of inflammatory signaling pathways in ulcerative colitis.

ABSTRACT: Ulcerative colitis (UC) is a chronic type of inflammatory bowel disease (IBD). This study identified core genes and pathways involved in UC by performing transcriptional profiling of colon biopsies from UC patients and healthy controls using data from the Gene Expression Omnibus (GEO) database. A total of 202 samples, including 129 UC patients and 73 healthy controls, were analyzed, measuring the expression of 40,991 genes using a 44K formatted microarray. Differential gene expression (DGE) analysis and gene set enrichment analysis (GSEA) identified several biomarkers potentially involved in UC development. PLCB3 was significantly downregulated, which suggested its role in maintaining intestinal homeostasis. In contrast, DUOX2 was upregulated, which indicated its involvement in the inflamm

SUBMITTER: Misaghian S 

PROVIDER: S-EPMC12404484 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature