Impact of vaccination and SARS-CoV-2 variants on severe COVID-19 outcomes: a cross-sectional study, Brazil, 2021-2022.

ABSTRACT:

Objective

To investigate association between vaccination, SARS-CoV-2 variants, and severe outcomes among Brazilian patients hospitalized due to COVID-19.

Methods

This was a cross-sectional study using Brazilian Ministry of Health data on patients hospitalized with severe acute respiratory syndrome due to COVID-19 between 2021 and 2022. Demographic, clinical, and outcome variables were analyzed, considering SARS-CoV-2 variants and vaccination status. Statistical tests included Pearson's chi-square test, Cochran-Armitage trend test, Mann-Whitney U test, Kruskal-Wallis test, and Poisson regression with robust variance to identify risk factors for invasive mechanical ventilation and death, estimating prevalence ratios (PR) and 95% confidence intervals (95%CI).

Results

A t

SUBMITTER: Moraes LP 

PROVIDER: S-EPMC12404605 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature