Acquisition phase-specific contribution of climbing fiber transmission to cerebellum-dependent motor memory in mice.

ABSTRACT: Climbing fiber (CF) transmission from the inferior olive (IO) triggers complex spikes (Cs) in Purkinje cells (PCs) driven by a burst of calcium spikes. In the context of motor learning, especially the compensatory optic response, CF transmission serves as an instructive signal selectively conveyed to PCs. While the significance of CF input in motor memory formation is widely acknowledged, a comprehensive understanding of its distinct contribution across different temporal windows, spanning from the initial learning phase to the retrieval period, remains incomplete. Therefore, we aimed to investigate the necessity of CF-induced instructive signals in motor learning by assessing their roles in memory acquisition, consolidation, and retrieval. We employed optogenetics to selectively inhibit C

SUBMITTER: Seo J 

PROVIDER: S-EPMC12404610 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature