Overexpression of TLR7 contributes to the development of preeclampsia through suppression of the PI3K-Akt signaling pathway.

ABSTRACT:

Objective

This study aims to uncover key genes contributing to preeclampsia development and elucidate their underlying mechanisms.

Methods

We conducted transcriptome analysis of placental tissues from preeclampsia patients and healthy pregnancies. Pregnant mice were administered a TLR7 agonist to induce preeclampsia-like symptoms. Additionally, we over-expressed TLR7 in HTR8/Svneo cells to assess its effects on cell functions. Co-analysis of transcriptomic differences between TLR7 agonist-treated mice, oe-TLR7 cells, and corresponding control groups was performed to identify key regulatory pathways.

Results

Our findings revealed that the Toll-like receptor (TLR) signaling pathway may serve as a central network hub, with TLR7 being the only significantly altered TLR be

SUBMITTER: Zhang X 

PROVIDER: S-EPMC12404633 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature