A longitudinal evaluation of gastrointestinal symptoms in children with autism spectrum disorder.

ABSTRACT: Gastrointestinal symptoms are frequently reported in children diagnosed with autism spectrum disorder. This study sought to determine the longitudinal trajectory of gastrointestinal symptoms without a medical etiology in children with autism compared to similar aged participants with typical development. A total of 475 children enrolled in this longitudinal study (322 autism spectrum disorder and 153 typical development groups) were evaluated at up to three time points between 2 and 12 years of age. Nine common gastrointestinal symptoms and formal medical gastrointestinal diagnosis were assessed using a physician-administered parent interview. A rigorous symptom classification was performed by physicians via clinical consensus. The frequency and persistence of gastrointestinal symptoms acr

SUBMITTER: Restrepo B 

PROVIDER: S-EPMC12404668 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature