Chemomechanical regulation of growing tissues from a thermodynamically-consistent framework and its application to tumor spheroid growth.

ABSTRACT: It is widely recognized that reciprocal interactions between cells and their microenvironment, via mechanical forces and biochemical signaling pathways, regulate cell behaviors during normal development, homeostasis and disease progression such as cancer. However, how exactly cells and tissues regulate growth in response to chemical and mechanical cues is still not clear. Here, we propose a framework for the chemomechanical regulation of growth based on thermodynamics of continua and growth-elasticity to predict growth patterns. Combining the elastic and chemical energies, we use an energy variational approach to derive a novel formulation that isolates the mass-conserving tissue rearrangement from the mass-accretion volumetric growth, and incorporates independent energy-dissipating stress

SUBMITTER: Olaranont N 

PROVIDER: S-EPMC12404680 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature