Sleep, pericyte subtypes and cognitive decline in adults with and without Alzheimer's disease.

ABSTRACT: Sleep fragmentation is common in older adults and is associated with cognitive impairment and dementia, as well as key histopathological correlates of dementia, including small vessel disease and cerebral infarcts. Vascular and blood-brain barrier dysfunction are thought to contribute to cognitive decline and dementia. Pericytes, a key vascular cell type, may play a key role. In model organisms, sleep disruption is associated with pericyte dysfunction and blood-brain barrier breakdown. Recent advances in single-nucleus RNA sequencing (snRNAseq) technology have identified two transcriptionally distinct subtypes of pericytes: extracellular matrix protein-expressing M-pericytes and solute carrier-expressing T-pericytes. However, the relationship between sleep, pericyte biology and cognition i

SUBMITTER: Hamid M 

PROVIDER: S-EPMC12404711 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature