A digital motor score for sensitive detection of progression in Huntington's disease.

ABSTRACT: Remote digital monitoring of Huntington's disease (HD) has potential to enhance the development of therapeutics, but no data-driven digital motor score exists to quantify the diversity of disease manifestations and track their progression. The HD Digital Motor Score (HDDMS), co-designed with people with HD and neurologists, is a composite score for measuring motor progression of HD in clinical research. It is derived from smartphone sensor-based motor tests included in a remote HD digital monitoring platform. Developing the HDDMS involved selecting features that quantify test performance according to desired measurement properties and combining these features in a weighted composite score using factor analysis. It was developed and subsequently validated using data from four separate studi

SUBMITTER: Giboin LS 

PROVIDER: S-EPMC12404731 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature