Structural covariance analysis for neurodegenerative and neuroinflammatory brain disorders.

ABSTRACT: Structural MRI can robustly assess brain tissue alterations related to neurological diseases and ageing. Traditional morphological MRI metrics, such as cortical volume and thickness, only partially relate to functional impairment and disease trajectories at the individual level. Emerging research has increasingly focused on reconstructing interregional meso- and macro-structural relationships in the brain by analysing covarying morphometric patterns. These patterns suggest that structural variations in specific brain regions tend to covary with deviations in other regions across individuals, a phenomenon termed structural covariance. This concept reflects the idea that physiological and pathological processes follow an anatomically defined spreading pattern. Advanced computational strategi

SUBMITTER: Mongay-Ochoa N 

PROVIDER: S-EPMC12404781 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature