Mass spectrometry imaging reveals alterations in protein and N-glycan molecular signatures in endometriosis tissues.

ABSTRACT: Endometriosis is a gynecological condition characterized by the uncontrolled growth of endometrial-like tissue outside the uterine cavity. Although highly prevalent, the biological mechanisms of endometriosis are poorly understood, and the disease is often misdiagnosed due to the unavailability of pre-operative diagnostic methods. Thus, better characterization of molecular markers of endometriosis is critical to improve our understanding of the disease and management of patients. Here, we used matrix-assisted laser desorption ionization mass spectrometry (MALDI MS) imaging to investigate protein and N-glycan molecular signatures in eutopic endometrium and endometriosis lesions from tissues prospectively collected from patients. MALDI MS imaging of intact proteins revealed neutrophil defens

SUBMITTER: Lin M 

PROVIDER: S-EPMC12404848 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature