Inflammation in frailty, cognitive impairment, clinical events and mortality among older adults with HIV in the ACTG HAILO cohort.

ABSTRACT:

Objectives

Associations between inflammatory markers and prevalent or incident frailty, cognitive impairment, clinical events and mortality in older people with HIV are poorly understood.

Design

An observational cohort study.

Methods

Participants ≥50 years from the ACTG HAILO cohort study were included. Participants completed annual evaluations for cognitive impairment and frailty. Clinical events included non-AIDS-defining cancers, diabetes and cardiovascular, liver and kidney diseases. Associations between inflammatory markers (hsCRP, IL-6, TNFR1, CXCL-9 and inflammatory index score [IIS]) at baseline and prevalence and incidence of frailty, cognitive impairment, any clinical event and non-accidental mortality were examined. We used 10-fold cross validation to exami

SUBMITTER: Han WM 

PROVIDER: S-EPMC12404850 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature