Prognostic value of the log odds of negative lymph nodes/T stage ratio (LONT) in postoperative esophageal cancer: a SEER-based study.

ABSTRACT:

Introduction

Surgery remains the primary treatment for patients with esophageal cancer (EC), yet postoperative prognosis is often unsatisfactory. Accurate prediction of cancer-specific survival (CSS) can assist clinicians in personalized treatment planning. This study aimed to develop an interactive web-based tool to estimate CSS in patients with T1~3N0~2M0 EC after surgery, based on the log odds of negative lymph nodes/T stage ratio (LONT).

Methods

A total of 2,221 patients with T1~3N0~2M0 EC were identified from the Surveillance, Epidemiology, and End Results (SEER) database. Patients were randomly divided into training and testing sets. Univariate Cox regression analysis was conducted to identify factors associated with CSS. Cox regression and random survival forest (RSF)

SUBMITTER: Lin Y 

PROVIDER: S-EPMC12404919 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature