A metagenome-wide association study of gut microbiota in hepatitis B virus-related cirrhosis in northwest China.

ABSTRACT:

Background and purpose

In recent years, research on the relationship between hepatitis B virus-related cirrhosis (HBV-LC) and gut microbiota has grown, but studies focusing on the Northwest Chinese population are scarce. This study characterized the gut microbiota composition and function in HBV-LC patients vs. healthy individuals in Northwest China, aiming to provide a scientific basis for region-specific precision therapies.

Materials and methods

A cross-sectional study enrolled 43 HBV-LC patients and 43 age-/sex-matched healthy controls (HC) from Gansu Province. Clinical parameters including liver function, blood routine, coagulation function, blood biochemistry were measured. Shotgun metagenomic sequencing was conducted to analyze gut microbiota taxonomic composition and

SUBMITTER: Feng M 

PROVIDER: S-EPMC12404923 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature