Clinical efficacy and regulatory mechanisms of Shi Pi Zeng Ye formula in treating functional constipation comorbid with depression: integrating clinical observation, mass spectrometry, bioinformatics, and molecular docking.

ABSTRACT:

Ethnopharmacological relevance

The Shi Pi Zeng Ye Formula (SPZY), a traditional Chinese herbal compound, is empirically used for qi and yin replenishment and has been prescribed for managing functional constipation (FC) comorbid with depression. Although its clinical efficacy is recognized, the active constituents and their precise mechanisms of action in treating FC comorbid with depression have yet to be fully determined.

Aim of the study

This research aims to elucidate the efficacy and mechanisms underlying the therapeutic effects of SPZY on FC comorbid with depression, employing a single-arm study design alongside mass spectrometry, network pharmacology, and molecular docking.

Materials and methods

In this study, 202 patients suffering from FC were recruited and t

SUBMITTER: Yao L 

PROVIDER: S-EPMC12404943 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature