Molecular mechanisms and therapeutic advances of peritubular capillary neogenesis in acute kidney injury.

ABSTRACT: Acute kidney injury is a clinical syndrome characterized by a rapid decline in renal function, driven by pathological mechanisms such as renal tubular epithelial cell injury, inflammatory responses, and microcirculatory dysfunction. In recent years, the role of angiogenesis in AKI recovery and regeneration has gained increasing attention. Angiogenesis plays a dual role in tissue repair and pathological remodeling, exhibiting complex spatiotemporal dynamics during AKI progression. This review synthesizes recent advances in understanding the role of angiogenesis in AKI, with the aim of identifying potential diagnostic and therapeutic strategies. Studies indicate that the ischemic-hypoxic microenvironment following AKI activates key signaling pathways, including hypoxia-inducible factor-1α, w

SUBMITTER: Ding Y 

PROVIDER: S-EPMC12404958 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature