Protective immune response in rainbow trout (<i>Oncorhynchus mykiss</i>) against the parasitic nematode <i>Anisakis simplex</i>.

ABSTRACT:

Introduction

Parasitic nematodes are prevalent in fish populations. The parasites are pathogenic but depress host responses, which limit clearance of the pathogens from the invasion sites. We hypothesized that one of several control strategies, which could augment protection, is immunization of the fish host with parasite antigens prior to live pathogen exposure.

Methods

We used rainbow trout Oncorhynchus mykiss as a host model and third stage larvae (L3) Anisakis simplex (Nematoda, Ascaridoidea, Anisakidae) as pathogen model. We used a total of 120 fish and immunized 40 of the fish with a homogenate (adjuvanted) of parasite larvae (i.p. injection), 40 fish received adjuvant only and 40 PBS. Following 38 days (d) half of the fish in each group were exposed to i

SUBMITTER: Kumas K 

PROVIDER: S-EPMC12404961 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature