Development and validation of a nomogram for predicting overall survival in patients with primary central nervous system germ cell tumors.

ABSTRACT:

Background

Primary central nervous system (CNS) germ cell tumors (GCTs) are common neoplasms in the CNS of pediatric and adolescent patients. This study aimed to identify prognostic factors associated with CNS GCTs and establish an effective nomogram for predicting overall survival (OS) in patients with CNS GCTs.

Methods

The development cohort including 1166 CNS GCTs patients was selected from Surveillance, Epidemiology, and End Results (SEER) program between 2000 and 2021. An additional 165 CNS GCTs patients treated at the Sun Yat-sen University Cancer Center (SYSUCC) between 1997 and 2019 were included as validation cohort.

Results

The nomogram incorporated the variables screened by multivariate Cox regression analysis, which included age, sex, histopathology, disse

SUBMITTER: Yao D 

PROVIDER: S-EPMC12404971 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature