Meta-inflammation and endotoxemia in a highly translational porcine model of diet-induced obesity.

ABSTRACT: Meta-inflammation (chronic, low-grade systemic inflammation) is increasingly recognized as an essential link between obesity and the development of various noncommunicable diseases. However, large animal models for studying obesity-related meta-inflammation are lacking. Minipigs have great potential as models for human diseases, warranting investigation of the performance of the Göttingen minipig as a model for obesity-associated meta-inflammation. Here, we fed 26 pigs a high-fat, fructose and cholesterol diet (HFFC) or a standard diet (SD) for 103 days, resulting in the HFFC group having a 45% higher body weight and 16% larger abdominal circumference by the end of the experiment. Meta-inflammation was shown in the HFFC group by elevated serum concentrations of the acute phase protein C-re

SUBMITTER: Starbæk SMR 

PROVIDER: S-EPMC12404983 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature