Shared and disease-specific pathways in frontotemporal dementia and Alzheimer's and Parkinson's diseases.

ABSTRACT: Neurodegenerative diseases (NDs), such as Alzheimer's disease (AD), Parkinson's disease (PD) and frontotemporal dementia (FTD), exhibit distinct yet overlapping pathological mechanisms. Leveraging large-scale plasma proteomics data from the Global Neurodegeneration Proteomics Consortium, we analyzed 10,527 plasma samples (1,936 AD, 525 PD, 163 FTD, 1,638 dementia and 6,265 controls) to identify disease-specific and shared proteins across NDs. We identified 5,187 proteins significantly associated with AD, 3,748 with PD and 2,380 with FTD that revealed both common and divergent proteomic signatures, which were confirmed by multiple analytical approaches and orthogonal validation. PD and FTD showed the highest overlap (r² = 0.44) and AD and PD the least (r² = 0.04). Immu

SUBMITTER: Ali M 

PROVIDER: S-EPMC12404994 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature