SLC38A4 as a prognostic biomarker and correlated with immune infiltration in colorectal liver metastasis.

ABSTRACT:

Background

Colorectal liver metastasis (CRLM) is the most frequent form of metastasis and the main reason for deaths associated with colorectal cancer. However, prognostic biomarkers originating from CRLM tissue remain limited. Additionally, the impact of the metabolism-associated gene SLC38A4 on patients with CRLM remains elusive.

Methods

Metabolism-related differentially expressed genes (MRDEGs) were identified between CRLM and adjacent normal liver (NL) tissues using GEO datasets (GSE38174, GSE41258). The prognostic significance of these MRDEGs in CRLM (GSE159216) was evaluated using Cox regression and Kaplan-Meier survival analyses. The differential expression of SLC38A4 was validated through multiple experiments, including qRT-PCR, Western blotting, and immunohistochemi

SUBMITTER: Liu Y 

PROVIDER: S-EPMC12405119 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature