Mendelian randomization analysis reveals causal roles of inflammatory cytokines in thyroid cancer pathogenesis.

ABSTRACT: Thyroid cancer is a common endocrine malignancy associated with various inflammatory factors. This research aimed to explore the causal relationships between 41 inflammatory factors and the risk of thyroid cancer using Mendelian randomisation (MR) analysis. MR analysis was performed using genetic data from two publicly available European genome-wide association studies (GWAS). Instrumental variables were selected based on single-nucleotide polymorphisms significantly associated with cytokine levels. Causal relationships were assessed using the inverse variance weighted method, with sensitivity analyses to evaluate heterogeneity and pleiotropy. The results suggest that interleukin-1 receptor antagonist (IL-1RA) and β-nerve growth factor (B-NGF) are risk factors for thyroid cancer, while mac

SUBMITTER: Liu B 

PROVIDER: S-EPMC12405125 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature