Prepandemic levels of cytokines and immunoglobulins and risk of SARS-CoV-2 infection and COVID-19 in the general population of Barcelona.

ABSTRACT:

Background

From a public health perspective it is remarkable that there are yet no longitudinal studies in the general population investigating the influence of the basal immune state, measured before the pandemic, on the risk of SARS-CoV-2 infection and COVID-19.

Objective

To investigate the specific and combined effects of personal levels of cytokines and immunoglobulins-measured in individuals' blood 4 years before the pandemic-on the risk of SARS-CoV-2 infection and COVID-19 in a general population.

Methods

We conducted a prospective cohort study in 240 individuals from the general population of Barcelona. Thirty cytokines and 31 immunoglobulins were quantified in prepandemic serum samples (collected in 2016-17) by high-throughput multiplex quantitative suspension

SUBMITTER: Porta M 

PROVIDER: S-EPMC12405241 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature