Diversity, expression, and structural modeling of sugar transporters in <i>Anisakis simplex</i> s. s. L3 and L4 larvae: an <i>in vitro</i> and <i>in silico</i> study.

ABSTRACT:

Introduction

Glucose transporter (GLUT) research in parasitic nematodes focuses on identifying and characterizing developmentally regulated isoforms, elucidating their regulatory and structural properties, and evaluating their potential as drug targets. While glucose transport mechanisms have been well characterized in the free-living nematode Caenorhabditis elegans, data on parasitic species remain limited. Anisakis simplex s. s., a parasitic nematode, relies on host-derived glucose to maintain energy metabolism. It is hypothesized that A. simplex s. s. utilizes specific glucose transporters to facilitate sugar uptake under varying nutritional conditions.

Materials and methods

In silico analysis identified five putative facilitated glucose transp

SUBMITTER: Polak I 

PROVIDER: S-EPMC12405323 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature