Elevated FDG uptake in non-tumorous lung regions does not predict immune checkpoint inhibitor-related pneumonitis in lung cancer patients.

ABSTRACT:

Background

Predictors for checkpoint inhibitor-related pneumonitis (cinrPneumonitis) are desperately needed. This study aimed to investigate the pretreatment standardized uptake value (SUV) on [¹⁸F]FDG-PET/CT of non-tumorous lung tissue as a predictive imaging marker for the development of cinrPneumonitis in 239 patients with lung cancer.

Methods

All patients with lung cancer receiving [¹⁸F]Fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) prior to immune checkpoint inhibitor (ICI) therapy were included and retrospectively analyzed. Pretreatment SUV_MEAN, SUV_MAX, SUV₉₅, SUV normalized by lean body mass (SUL_MEAN, SUL_MAX) and clinical variables were compared for patients

SUBMITTER: Volter F 

PROVIDER: S-EPMC12405330 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature