PD-L1⁺ neutrophils mediate immune regulation of CD8⁺ T cells in halo nevi.

ABSTRACT:

Background

Halo nevi are clinically common and are characterized by a circle of leukoderma around the central melanocytic nevus. Studies have shown that the pathogenesis of halo nevi is similar to that of vitiligo and is associated with the role of CD8⁺ T lymphocytes in melanocyte destruction. Histopathological findings have revealed neutrophil infiltration in halo nevi; however, the specific immune mechanisms involving neutrophils have not been thoroughly investigated. In the present study, we investigated the role of neutrophils in halo nevi using histopathological and immunological analyses.

Methods

To this end, we examined the infiltration patterns of immune cells in halo nevi, with a particular focus on IFN-γ-induced PD-L1 expression in neutrophils and its potential imm

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC12405382 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature