Prognostic value of platelet to lymphocyte ratio (PLR) in breast cancer patients receiving neoadjuvant therapy: a systematic review and meta-analysis.

ABSTRACT:

Background

The platelet to lymphocyte ratio(PLR) is widely recognized as an important biomarker of systemic inflammation and has been associated with treatment responses in breast cancer (BC) patients undergoing neoadjuvant therapy. However, existing evidence remains inconsistent. This meta-analysis aims to systematically investigate the prognostic value of PLR in BC patients receiving neoadjuvant chemotherapy (NACT).

Methods

A broad and systematic search of the literature was carried out using PubMed, Embase, Web of Science, and the Cochrane Library, covering all available records from the inception of each database through April 7, 2025. Study selection was guided by a set of predetermined inclusion and exclusion parameters. Primary outcomes included overall survival (OS),

SUBMITTER: Zhao Z 

PROVIDER: S-EPMC12405421 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature