A magneto-responsive nanomesh biosensor for simultaneous mechanical stimulation and electrochemical detection.

ABSTRACT: Mechanical cues are critical regulators of cell fate and behavior through the orchestrated and continual conversion of physical forces into biochemical responses. However, due to the poor compatibility between mechanical and biochemical techniques, existing methods are often limited in characterizing the occurring biochemical signals during mechanical stimulation. Herein, this work presents a magneto-responsive nanomesh (MRnM) biosensor capable of mechanically stimulating cells in vitro and tissues in vivo and simultaneously detecting the triggered biomolecules. Under external magnetic fields, the sensor exhibits excellent magnetic responsiveness with remote, controllable and tailored deformation, while maintaining prominent and stable electrochemical sensing performance. As a proof of con

SUBMITTER: Jin KQ 

PROVIDER: S-EPMC12405483 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature