Progressive changes in phenotype, transcriptome and proliferation capacity characterise continued maturation and migration of intestinal cDCs in homeostasis.

ABSTRACT: Conventional dendritic cells (cDCs) are important antigen presenting cells which link innate and adaptive immunity by transferring antigenic information from peripheral organs to T cells in lymph nodes (LNs). However, despite their central function in the induction of adaptive immune responses, the kinetics and molecular regulation of the cDC life cycle and migration remain poorly understood. Using a variety of in vivo techniques, we examine the kinetics of cDC turnover in the intestine and address the molecular changes throughout the various stages of the cDC life cycle - from tissue entry and differentiation to CCR7 upregulation and subsequent migration into draining LNs. Our data demonstrate that the life cycle of gut cDCs is highly dynamic, characterised by continuous alterations in tr

SUBMITTER: Hager FT 

PROVIDER: S-EPMC12405583 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature