Regulator of G protein signaling 2 as a suppressor of sphingosine-1-phosphate 2- and 3-mediated signaling in colon cancer cells.

ABSTRACT: Sphingosine-1-phosphate receptor 2 and 3 (S1P₂ and S1P₃) are G protein-coupled receptors that mediate extracellular sphingosine-1-phosphate (S1P) signaling into cells. S1P₂ and S1P₃ are highly expressed in colon cancer cells, but their roles in cancer progression-related cellular phenotypes are not well understood. Recent studies suggest that regulator of G protein signaling 2 (RGS2) interacts with G protein-coupled receptors, either directly or indirectly, to regulate their signaling. However, the precise role of RGS2 in S1P₂ and S1P₃ signaling remains uninvestigated. In this study, we examined the interaction of RGS2 with S1P₂ and S1P₃ using bioluminescence resonance energy transfer analysis and asses

SUBMITTER: Eo J 

PROVIDER: S-EPMC12405630 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature