Resting-state Alpha Reactivity Is Reduced in Parkinson's Disease and Associated With Gait Variability.

ABSTRACT: BackgroundThe extent to which the cholinergic system contributes to gait impairments in Parkinson's disease (PD) remains unclear. Electroencephalography (EEG) alpha reactivity, which refers to change in alpha power over occipital electrodes upon opening the eyes, has been suggested as a marker of cholinergic function. We compared alpha reactivity between people with PD and healthy individuals and explored its potential association with gait measures.MethodsEyes-closed and eyes-open resting-state EEG data were recorded from 20 people with idiopathic PD and 19 healthy individuals with a 64-channel EEG system. Alpha reactivity was calculated as the relative change in alpha power (8-13 Hz) over occipital electrodes from eyes-closed to eyes-open. Gait spatiotemporal measures were obtained with

SUBMITTER: Lirani-Silva E 

PROVIDER: S-EPMC12405644 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature