Self-Assembly of Heterochiral and Homochiral Peptides Conjugated to PNA Dimers and Their Integration in Peptide-Based Hydrogels.

ABSTRACT: Hybrid biomolecules composed of short peptides and nucleic acid analogues can self-assemble and are good candidates to produce new materials thanks to their biocompatibility and versatility. The assembly occurs by exploiting hydrogen bonds and stacking interactions between nucleobases and amino acids. The organization of the molecules at the supramolecular level is dictated by the structure of the assembling units. In this work we explored the effect of chirality on the self-assembly of PNA-peptide conjugates. We focused on homochiral and heterochiral peptides conjugated to PNA dimers and we characterized by spectroscopic techniques the assembled objects. Furthermore, we investigated the ability of the conjugates to form hydrogels in combination with the peptides. The architecture of the a

SUBMITTER: Miglioli I 

PROVIDER: S-EPMC12405829 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature