Distinct satellite DNA composition between core and germline restricted chromosomes in Bradysia (Sciara) coprophila.

ABSTRACT: Programmed DNA elimination, a phenomenon wherein cells eliminate a subset of genetic material during certain stages of development, is observed in a broad range of organisms. The fungus gnat Bradysia (formerly Sciara) coprophila undergoes a series of programmed DNA elimination events during their development, including elimination of germline-restricted chromosomes (called L chromosomes) in the soma and elimination of paternal chromosomes during male meiosis. However, a lack of understanding surrounding the nature of eliminated chromosomes poses a barrier to studying programmed DNA elimination in this system. Highly repetitive satellite DNA, which often shows chromosome-specific distribution, is a possible candidate for sequences involved in programmed DNA elimination. In this study, we ut

SUBMITTER: Kerrebrock A 

PROVIDER: S-EPMC12405879 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature