Genetic and phenotypic insights into Cyberlindnera jadinii as a promising yeast for industrial biotechnology.

ABSTRACT: Cyberlindnera jadinii is a nonmodel yeast species recognized for its robust growth under diverse stress conditions, making it a promising candidate for various industrial applications. Here, we performed genome sequencing for genetic analysis and high-throughput phenotypic assays to examine 20 wild strains, focusing on the diversity of their genome, morphology, and fitness traits. We found that C. jadinii comprises a mixed population of diploid and triploid cells, with the latter exhibiting significantly larger cell sizes than the former, suggesting that ploidy plays a crucial role in determining cell morphology. In contrast, fitness traits, including growth under 24 different conditions, were more closely associated with SNP-defined lineages than with ploidy. Cyberlindnera jadinii exhibit

SUBMITTER: Wu J 

PROVIDER: S-EPMC12405887 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature