Intrauterine Growth-Restricted Female Yucatan Miniature Pig Neonates Fed Parenteral Nutrition Exhibit Early Catch-Up Growth Leading to Obesity and Ectopic Fat Deposition in Adulthood.

ABSTRACT:

Background

Total parenteral nutrition (TPN) is often used as a lifesaving nutritional regimen in intrauterine growth-restricted (IUGR) neonates. However, nutrition perturbations during the early critical period may permanently program metabolism via methyl-dependent epigenetic alterations that can lead to obesity and dyslipidemia in adulthood. Methyl group availability can be increased by adding betaine and creatine to TPN.

Objectives

We sought to determine whether TPN in early life would have long-term effects on the development of obesity, whether IUGR will exacerbate these TPN-induced effects, and whether supplementing betaine and creatine to TPN will alleviate these effects.

Methods

Twenty four 7-d-old female piglets were randomly assigned to suckled, TPN-control

SUBMITTER: Randunu RS 

PROVIDER: S-EPMC12405908 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature