Comparative transcriptomic profiling of drug-metabolizing enzymes and drug transporters in rabbit ocular subtissues, liver, and duodenum.

ABSTRACT: The increasing prevalence of diabetes and the aging population have led to a growing market for ophthalmic pharmaceutical drugs. However, the development of ophthalmic drugs is hampered by the poor understanding of drug-metabolizing enzymes (DMEs) and drug transporters (DTs) in complex ocular tissues. The rabbit is the most commonly used preclinical model for human ocular diseases. The purpose of this study was to compare relative gene expression of DMEs and DTs in various rabbit ocular subtissues, including cornea, iris-ciliary body, vitreous humor, and retina-choroid complex. Rabbit liver and duodenum samples were also included to investigate gene expression differences among the eye, liver, and duodenum. The mRNA transcriptome of the 6 tissue types from 6 rabbits (3 males and 3 females)

SUBMITTER: Li M 

PROVIDER: S-EPMC12405909 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature