Normosol-R vs Lactated Ringers in the Critically Ill: A Randomized Trial.

ABSTRACT:

Background

Balanced crystalloid solutions may improve clinical outcomes compared with saline for some critically ill adults, but it is unclear whether differences in composition between balanced crystalloid solutions affect outcomes.

Research question

Does the choice of balanced crystalloid solutions (Normosol-R vs lactated Ringers) impact acid-base status, organ function, or outcomes for critically ill adults?

Study design and methods

This pragmatic, cluster-randomized, multiple-crossover trial at an academic medical center in the United States compared the use of Normosol-R vs lactated Ringers among critically ill adults. The primary outcome was the plasma bicarbonate (HCO₃^-) concentration between enrollment and 7 days. Secondary outcomes inclu

SUBMITTER: Qian ET 

PROVIDER: S-EPMC12405922 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature