Exploratory Study of Prognostic Plasma Biomarkers in Patients with Pulmonary Arterial Hypertension.

ABSTRACT: Pulmonary arterial hypertension (PAH) is characterized by progressive pulmonary vascular lumen occlusion, ultimately leading to right ventricular failure and death. Risk stratification is essential for the management of patients with PAH. So far, B-type natriuretic peptide and its N-terminal pro-form are the only circulating biomarkers used as part of composite PAH risk assessment tools. Identification of other biomarkers of vascular or systemic origin may be valuable to provide additional information on disease severity and prognosis. Using proximity extension assay, >700 proteins related to oncology and neurology were measured in the plasma of 60 patients with PAH and 28 age- and sex-matched controls. Among the 114 proteins significantly up-regulated in patients with PAH, 14 were indepen

SUBMITTER: Kuwabara Y 

PROVIDER: S-EPMC12405927 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature